half containing the powder. The edges of both the halve are pressed together so as to make a perfect
seal.
(b) Dry seal Cachets:
They consist or two halves, the upper half and the lower half. The former one is little larger in
diameter than the lower half. The powder is filled in a lower half and upper half is fitted over it like a lid
on a box.
Cachets are dispensed in a box. If necessary the empty spaces are filled by cotton wool so as to
fix them properly in the boxes. The boxes are labeled with direction of use “ Immerse in water for few
seconds and then swallow with draught of w
ater”
.
Tablet trituates:
They are prepared by moulding powder into tablets. They are flat and circular disk shaped.
Usually they are prepared for potent medicaments and highly toxic drugs by diluting the with diluents
like lactose, dextrose sucrose etc. the drug and the diluents are mixed and the moistened with suitable
dilution of alcohol (usually 50-60% alcohol is used) and mixed and then as to get a damp mass. This
damp mass is filled in the perforations of the mould with a spatula. The excess amount damp mass is
squeezed with the edge of the spatula. The filled perforated plate is superimposed on another plate
having the same number of projecting pegs as that perforation. A little pressure is put over the upper
plate which will allow the plate to go downward leaving the moulded tablets on the top of the pegs.
These moulded tablets are carefully spread on the clean surface and dried either in open air or in oven
at a controlled temperature.
Official preparations
Simple powders:
Simple powders only one ingredient either in crystalline or amorphous form. These powders
should preferable be reduced to fine powder, weighed properly and supplied in a single dose packet
separately. The wrapping of powders may be single wrapped or double wrapped (lined with waxed
paper) according to the properties of the drugs. If the drug is resistant to atmospheric conditions, it can
be wrapped singly and if sensitive to those conditions, must be double wrapped
For example:
Rx
Paracetamol …500mg
Method:
Weigh accurately the required amount of paracetamol powder which is already in its fine state.
If not, then first reduce to fine powder and weigh. Wrap each dose in a white demy paper Compound
powders.
Compound powders
:
contain two or more ingredients supplied in the form of fine state of powder in divided dose, i.e.
each dose is supplied in a single packet.