Study Set Content:
USP Apparatus 1 –
Rotating Basket
Standard:
40 mesh, 900 ml Water
Application:
Tablets (Immediate Release),
Useful at higher rotation frequencies for
modified-release oral dosage forms.
USP Apparatus 2
Rotating Paddle
Standard:
Teflon or Stainless, 900 ml Water, Wire sinker for floaters.
Application:
Capsule (Immediate release
More useful at higher rotation frequencies for modified-release oral dosage forms (100 rpm), Immediate release dosage forms that tend to
float or distingrate slowly.
USP Apparatus 1- Basket
o
Disadvantage: Formulation may_____ the screen; small disintegrated particles
clog, fall out
USP Apparatus 2 – Paddle
o
sinker Disadvantages: (blank) dosage forms require; _____ may be problematic;(blank)of the dosage form in the vessel
Floating, Cone formation, positioning
