Study Set Content:
must be controlled for consumer acceptance of the product, and to facilitate packaging
Thickness
Determined with a
a Micrometer Caliper (Vernier caliper) or thickness gauge
Tablet Thickness Test Requirement:
+/- 5% of standard thickness
Factors affecting Tablet Thickness
• Diameter of the die
• Amount of fill permitted to enter the die
• The compaction characteristics of the fill material
This test is also known as “Crushing Strength Test”
Tablet Hardness Test
• It is to test the breaking point and structural integrity of a tablet “under conditions of storage, transportation, and handling before usage”
Tablet Hardness Test
has been defined as the force required to break a tablet in a diametric compression table
Tablet hardness
Tablet Hardness Test It is similar to (blank), but they are not the same thing.
friability testing
Factors affecting Tablet Hardness
• Concentration of the binder
• Moisture Content
• Compression Force
Compressible spring between 2 springs
Stock Monsanto Hardness tester
Principle resembles simple pliers
Pfizer Hardness tester
Force generated by a manually operated Air pump and increase in pressure
Strong Cobb hardness Tester
– Suspended motor driven weight uniformity transmits pressure. It uses Anvil.
Erweka Hardness Tester
Motor-driven anvil crushed tablet in horizontal position
Schleuniger/Heberlein Hardness Tester
Compressed uncoated tablet ACCEPTABLE HARDNESS
4-10 kg
Buccal Tablets
7-10 kg
Chewable Tablets
2-3 kg
Sublingual
2-3 kg
the condition of being friable, describes the tendency of a solid substance to break into smaller pieces under duress or contact, especially by rubbing
Friability
The opposite of friable is
indurate
