Study Set Content:
a disease of cellular mutation, proliferation, and aberrant
Cancer
describes a subset of neoplastic lesions
Cell growth
new growth or autonomous growth of tissue
NEOPLASIA
the lesion resulting from the neoplasia
Neoplasm
the tissue of origin is frequently followed by the suffix “oma”
Benign
If it is from the epithelial origin they are called carcinomas - whereas those derived from mesenchymal origin are referred to as sarcoma
Malignant
Secondary growths derived from a preliminary malignant neoplasm
METASTASES
lesion characterized by swelling or increase in size, may or may not be neoplastic
Tumor
A physical or chemical agent that causes or induces neoplasia
CARCINOGEN
Carcinogens that interact with DNA resulting in mutation
Genotoxic
Carcinogens that modify gene expression but do not damage DNA
Nongenotoxic
Mutagenic
Genotoxic
can be complete carcinogens
Mutagenic
Nonmutagenic
Nongenotoxic
Threshold, reversible
Nongenotoxic
Tunorgenicity is dose responsive
Genotoxic
No theoretical threshhold
Genotoxic
Tuorigenicity is dose responsive
Nongenotoxic
May function at tumor promotion stage
Nongenotoxic
No direct DNA damage
Nongenotoxic
