Study Set Content:
Considers scientific decision-making within a societal and legal framework. Relies heavily upon risk assessment.
Regulatory Toxicology
Concerned with the compilation and synthesis of information regarding gene and protein expression in order to understand molecular mechanisms involved in toxicity.
Toxicogenomics
identify biomarkers that predict toxicity and genetic susceptibility to harmful substances.
Toxicogenomics
Deals with the use of modern computational approaches and information technologies to elucidate mechanisms of toxicity
Computational Toxicology
Computational Toxicology May also be referred to as
Toxicoinformatics.
Are toxic substances that are produced by biological systems.
TOXIN
produced and released from the fungus Aspergillus or Fungi that grows on foods such as corn and nuts.
Aflatoxin
Exposure to aflatoxin is associated with an increased risk of
liver cancer
Substances that are foreign to a given organism that can be toxic or not, and it is synthetic
XENOBIOTICS
are xenobiotics developed to treat disease
Pharmaceuticals
- used to deter pests
Pesticides
Toxic chemicals may be naturally produced but they are not produced by biological systems. These are toxic substances that are a by-product of human activities
TOXICANT
produced by combustion through ordinary processes or human activities
Polyaromatic Hydrocarbons
OTHER CLASSIFICATIONS
o By Physical state
o By Chemical stability or reactivity
o By General chemical structure
o Ability to cause significant toxicity
o Basis of their biochemical mechanisms of actions
o Descriptive categories
Assess relationship between toxicant exposure (dose) to the response (outcome) and the probability of an adverse event to occur
Toxicologist
which is the quantitative estimate of the potential effects of a chemical on human and environmental health at particular exposure levels (e.g., pesticide residues in food and chemical contaminants in drinking water).
RISK
Identifies the cellular, biochemical, and molecular mechanisms by which chemicals exert toxic effects on living organisms.
Mechanistic Toxicologist
Useful in the design and production of safer alternative chemicals and in therapies for chemical poisoning and treatment of disease.
Mechanistic Toxicologist
Conducts toxicity testing that provides comprehensive information for the evaluation of a chemical’s safety and to meet important regulatory requirements.
Hazard Assessment Toxicologist
is a chemical or action that causes harm, whereas the () is the likelihood for a hazard to result in harm.
Hazard, risk
