Study Set Content:
In the second stage, phosphoglucomutase catalyzes the transfer of the phosphate group from carbon 6 to carbon 1 on the glucose molecule. G-6-P is converted to
glucose -1-phosphate
G-1-P reacts with
uridine triphosphate (UTP)
G-1-P reacts with uridine triphosphate (UTP) to give
uridine diphosphate glucose (UDPG) and pyrophosphate (PPi)
G-1-P reacts with uridine triphosphate (UTP) to give uridine diphosphate glucose (UDPG) and pyrophosphate (PPi). The reaction is catalyzed by
uridine diphosphate-glucose pyrophosphorylase, or glucose1-P uridyltransferase.
UDPG-activated glucose is transferred to preexisting
glycogen
DPG-activated glucose is transferred to preexisting glycogen. One glycosidic linkage to
carbon 4
UDPG-activated glucose is transferred to preexisting glycogen. One glycosidic linkage to carbon 4 of a
terminal glucose
UDPG-activated glucose is transferred to preexisting glycogen. One glycosidic linkage to carbon 4 of a terminal glucose of a
glycogen chain is formed
UDPG-activated glucose is transferred to preexisting glycogen. One glycosidic linkage to carbon 4 of a terminal glucose of a glycogen chain is formed. This reaction is catalyzed by
glycogen synthase
UDPG-activated glucose is transferred to preexisting glycogen. One glycosidic linkage to carbon 4 of a terminal glucose of a glycogen chain is formed. This reaction is catalyzed by glycogen synthase, a (blank) that requires the presence of the preexisting glycogen polymeric structure, which keeps adding glucose molecules via α1→4 bonds.
glucosyl transferase
The activity of glycogen synthase requires preformed
glycogen chains.
an initiator protein which acts as an acceptor of the first glucose molecule prior to the glycosidic linkage with a tyrosine protein
Glycogenin
The process is
autocatalytic,
The process is autocatalytic, using (blank) as glucose donor.
UDPG
Glycogenin also catalyzes the successive addition of units to form a linear chain from six to
seven glucose molecules
Glycogenin also catalyzes the successive addition of units to form a linear chain from six to seven glucose molecules bound by
α1→4 bonds.
continue acting on the chain anchored to glycogenin
Glycogen synthase and the branching enzyme
Glycogen synthase and the branching enzyme continue acting on the chain anchored to glycogenin, giving the polymer its final
characteristic structure
Each glycogen molecule is covalently linked to an initiator protein, which is why the number of particles of glycogen in the cell depends on the availability of
glycogenin
Phosphorylation of glucose at C6 to G6P
Hexokinase
