Study Set Content:
Symptoms: jaundice, loss of motor skills, feeding difficulties, learning disabilities, hepatosplenomegaly
NIEMANN-PICK DISEASE (NPD)
NIEMANN-PICK DISEASE (NPD) inheritance
autosomal recessive
Eicosanoid derivatives formed via the lipoxygenase pathway
LEUKOTRIENES
Only (BLANK)-lipoxygenase forms leukotrienes
5
Characterized by the presence of three-conjugated double bonds.
LEUKOTRIENES
cause bronchoconstriction as well as being potent proinflammatory agents, and play a part in asthma; formed from eicosaenoic acids in leukocytes, mastocytoma cells, platelets and macrophages'
Leukotrienes
Parent fatty acids into what
Arachidonic acid
Eicosapentaenoic acid
Dihomo-y-linolenic acid
Arachidonic acid
Eicosapentaenoic acid
Dihomo-y-linolenic acid
Cytochrome P-450 monooxygenases
Cyclooxygenases
5-Lipoxygenases
Cytochrome p-450 monooxygenases into
Epoxides
Cyclooxygenases
Prostaglandins and thromboxanes
5-lipoxygenases
Leukotrienes
- The inositol present in PI is the stereoisomer,
myoinositol
Important constituent of cell membrane; in higher phosphorylated form:
phosphatidylinositol 4,5- bisphosphate (PIP2 ):
serve as signaling molecule in chemical communication
phosphatidylinositol 4,5- bisphosphate (PIP2 ):
- Precursor for diacylglycerol and inositol triphosphate that act as second messengers for some hormones
Phosphatidylinositol (
ts structure resembles phosphatidylethanolamine but possess an (blank)n position 1 instead of the ester link.
ether link
glycine
taurine
Ergosterol when irradiated with ultraviolet light, ring B is opened to form
Vitamin D2 (ergocalciferol)
Ergosterol when irradiated with ultraviolet light, ring B is opened to form vitamin D2 (ergocalciferol) in a process similar to that which forms vitamin
D3
