Study Set Content:
replaceable liners
micronized product outlet
Vortex finder
grinding chamber
grind air or gas manifold
has waterproofing characteristics retard penetration by the GI fluids delay drug dissolution and absorption
Mg stearate
A surface-active agent aka
“surfactant
A surface-active agent (“surfactant”), like
sodium lauryl sulfate
A surface-active agent (“surfactant”), like sodium lauryl sulfate, facilitates (blank) by the GI fluids to overcome the problem
wetting
After the hard capsule shell disintegrates/dissolves, the GI fluids must displace the air that surrounds the dry powder and penetrate the drug before it can be
dispersed and dissolved too.
powder
paste
pellet
tablet
capsule
Inserting tablets or small capsules into capsules is sometimes useful: ● To separate
chemically incompatible agents
To add premeasured amounts o
potent drug substances
are usually placed in a capsule
Modified-release coated pellets
What can be filled in SGC
1. Water-immiscible volatile and non-volatile
2. Water-miscible non-volatile ex. PEG, non-ionic surfactant (polysorbate 80)
3. Water-miscible and relatively non-volatile ex. Propylene glycol, Isopropyl Alcohol (IPA)
Water-miscible non-volatile
ex. PEG, non-ionic surfactant (polysorbate 80)
