Study Set Content:
Alternative to injection, rapid systemic drug effect
Advantages of rectal suppositories
● Circulation route (superior vs middle vs inferior)
Physiological
Lipid-water solubility
Physicochemical
Particle size
Physicochemical
pH and lack of buffer capacity of rectal fluids
Physiological
Colonic content
Physiological
(blank) particle size can lead to production problems!
too fine
Types of suppository bases
fatty or oleaginous
miscellaneous
water-soluble/miscible
most used base
fatty or oleaginous
preferred for vaginal supp
water-soluble/miscible
lipophilic + hydrophilic bases
miscellaneous
mixed triglycerides of oleic, palmitic, stearic acids
cocoa butter
triglycerides from palm, palm kernel, and coconut oils with self-emulsifying glyceryl monostrearate and polyoxyl stearate
fattibase
eutectic mixtures of mono-, di-, tri-glycerides derived from natural vegetable oils, each type having slightly different properties
suppocire OSI
triglycerides of saturated fatty acids C2-C18 with varied portions of the corresponding partial glycerides
witepsol H15
cocoa butter melting range
34-35
fattibase melting range
35.5-37
suppocire OSI
33-35
wecobee W melting range
31.7-32.8
witepsol H15
33-35
