Study Set Content:
Cocoa butter, NF
Fat from roasted seed of
Theobroma cacao
Triglyceride primarily of
oleopalmitostearin and oleodistearin
Exhibits polymorphism
What is the stable form?
• What minimum temperature can you melt it to maintain the stable form?
can lower melting point of cocoa butter
Phenol and chloral hydrate
Add (blank) as solidifying agents to remedy
cetyl ester wax or beeswax
Other important fat-soluble bases
•Fattibase
•Wecobee
•Witepsol
Glycerinated gelatin
Prepared by granular gelatin (blank) in glycerin (blank) and adding water or a solution or suspension of the medication (blank)
20%, 70%, 100%
most frequently used in the preparation of vaginal suppositories
Glycerinated gelatin
Slow release of medication
Glycerinated gelatin
Hygroscopic
Glycerinated gelatin
gelatin (60%), glycerin (20%), medicated aqueous portion (20%)
For urethral suppositories
Easier to insert than cocoa butter!
Glycerinated gelatin
polymers of ethylene oxide and water
Polyethylene glycol (PEG)
Prepared in different MW, usually in combinations
Polyethylene glycol (PEG)
MW 300, 400, 600
clear colorless liquids
MW > 1000
waxlike white solids
Convenient to store (no need to refrigerate) and administer
Polyethylene glycol (PEG)
Does not melt at body temp. but slowly dissolves in body fluids
Polyethylene glycol (PEG)
Do not leak from orifice unlike cocoa butter
Polyethylene glycol (PEG)
If contains < 20% water, (blank) before administration to patient
dip in water
