Study Set Content:
Important formulation variables
Physical state
Solubility
Volume contraction
Volume contraction
Viscosity & Brittleness
Drug release rates
Solid at storage Melt/dissolve in the body
Physical state
Results to different release patterns
Solubility
The smaller, the faster solubility/miscibility
Particle Size
Preparation of suppositories:
Most frequently used
Molding
Molding
- melt the base
- incorporate medicaments
- pour the melt into molds
- allow to cool and congeal into shape
- remove the formed suppositories from mold
- pack and store properly
suitable for preparation by molding
Cocoa butter, GG, PEG and most other bases
is usually necessary for GG base
Lubrication of mold
Molds are usually filled by volume so make sure you know
calibrate your mold depending on the choice of suppository base
We usually melt our ingredient in a
water bath (using least possible heat)
Constant stirring during pouring helps achieve
uniform dose!
Fill (blank) just in case!
excessively
Pour when the mixture is about to (blank) to avoid settling
congeal
Challenge yourself
What happens to the finished suppositories if the pouring of the melt into the mold is not continuous?
may lead to a product easily broken on handling.
Preparation of suppositories:
: Melt fusion method
For large scale/industrial production
Melt fusion method
melt fusion method steps
- forming
- dosing
- cooling
- sealing
- finishing
perforating, notching, cutting of the molds into appropriate count strips
Finishing
Treat vaginal infections, spermicidal, estrogenic
Vaginal suppositories
Most commonly used base is PEG
Vaginal suppositories
