With surfactants and parabens
Vaginal suppositories
Vaginal suppositories usually buffered to
pH 4.5
If formulating with fatty base, instruct patient to wear a
sanitary napkin
Usually ovoid, prepared by tablet compression
Vaginal inserts or tablets
Base or filler:
lactose
Disintegrating agent:
starch
Dispersing agent:
polyvinylpyrrolidone
Tablet lubricant:
magnesium stearate
Gelatin-containing medication
Vaginal/Rectal capsules
Must be wetted lightly
Vaginal/Rectal capsules
Holes can be punched prior insertion → facilitate fluid movement into capsule
Vaginal/Rectal capsules
Prepared similar to suppositories except the melt is poured in a tube
Medication sticks
Melting bases:
waxes, cocoa butter, petrolatum, PEGs, sodium stearate/glycerin mixture
waxes
Opaque
cocoa butter
Opaque
petrolatum
Opaque
sodium stearate/glycerin mixtures
Clear
PEGs
Opaque
main examples of solutions
syrup
elixir
spirit
aromatic waters
tincture
Sugar + water
Syrup