Study Set Content:
Penetrability in a site or
body region
Grittiness especially in
topical preparations
the process of reducing particle size
Comminution
Mortar & pestle
Trituration
for gummy substances,
use volatile solven
Pulverization by
intervention
paste is formed using a
suitable non-solvent
LEVIGATION
Types of mortar and pestle
no pores, no stain
fragile
for solns, susps
Types of mortar and pestle
no pores, no stain
fragile
for solns, susps
Glass
with pores, can stain
for reducing size of
crystals/solids
Wedgewood
less pores, glazed
for blending powders,
soft aggregates or
crystals
Porcelain
Common levigating agents
Non-polar solvents
for water-soluble
powders
Mineral Oil
polar solvent for oil-soluble powders
Glycerine
Polar solvent
Propylene glycol
for homogeneity & dose uniformity
Blending
5 Methods of blending powder
OK for eutectic
mixtures
NOT for potent
drugs and large
qty
Spatulation
OK for blending
with
comminution
Trituration
OK for potent
drugs + large
diluents
Geometric dilution
OK for very
light powders
NOT for potent
drugs
Sifting
Thorough but
time- consuming
Industrial scale
Tumbling
owders start to melt or become pasty/sticky when mixed
Eutectic mixtures
