Study Set Content:
How to remedy:
• use an inert diluent, e.g., light Mg oxide or Mg carbonate
• physical separation of ingredients
adding the diluent in portions to the potent drug with mixing in
between
Geometric dilution
Pro-tip for geometric dilution
add an inert colored powder to the diluent before mixing for visual inspection of the
mixing process.
wide-mouthed container or zip-locked bags can be used
Tumbling
Mg oxide or Mg
carbonate
Eutectic mixtures
Dispense the
ingredients in tight
containers
Hygroscopic &
Deliquescent
substances
Triturated very lightly on
a pill tile by using a
spatula
Eutectic Mixtures
Double wrap the papers
Eutectic MIxtures
Use dessicants
Hygroscopic &
Deliquescent
substances
Store in a dry place
Hygroscopic &
Deliquescent
substances
Dilute the powder with
an inert drying powder
Hygroscopic &
Deliquescent
substances
Dispense separately
Eutectic Mixtures
use an anhydrous salt
form of the drug
Efflorescent powder
Include a drying bulky powder
Efflorescent powder
use a light, noncompacting method of mixing the powders
Efflorescent powder
undesirable separation of the different components of the blend
Segregation
Fine particles tend to sift or
percolate through coarse particles
and end up at the bottom of the
container and actually (blank) the
larger particles to the surface.
lift
This occurs during powder transfer
where fine, aerated powders with
differences in particle size or density may
result in a (blank) pattern
striation
(blank) particles remain suspended
in air longer and do not settle as quickly
as the (blank) particles
finer lighter, larger denser
usually indicated for asthma and other bronchial disorders
Aerosol powders
