Study Set Content:
besides “normal” release
Modified
any time besides immediate;
enteric-coated
Delayed
reduce frequency of dosing
Extended
to site of action or specific region in
the body
Targeted release
immediate + delayed
Repeat action
Reduced fluctuation in drug flood levels
advantage
reduced dosing frequency
extended release advantages
Loss of flexibility in adjusting the drug dose
disadvantage extended release
Reduced ADR/SE
Advantage extended release
Dose dumping - a risk of sudden and total drug release
disadvantage
Reduced overall health cost
advantage
contains a large number of coated
and uncoated drug beads
Spansule
each bead is coated with a film that
disintegrates, revealing a powder
inside à dissolution
Coated beads, granules and microspheres spansule
drug is enclosed in microscopic particles by
formation of thin coatings of wall material around
the substance
Microencapsulated drug
Wall forming material:
• Gelatin
• Synthetic polymers (Polyvinyl alcohol, ethylcellulose,
polyvinyl chloride)
pioneer oral osmotic pumped drug
delivery
OROS system
Composed of a core tablet surrounded by a semi-
permeable membrane coating having a (blank)
hole produced by laser beam.
0.4 mm diameter
(containing the drug)
Active layer
(containing a polymeric osmotic
agent)
Push layer
The system operates on the principle of
osmotic
pressure.
