Study Set Content:
Lubricants of the weight of the
granulation.
0.1% to 5%
FD&C
colorants
most commonly used
Wet granulation
for moisture and heat-sensitive drugs
Dry Granulation
sticking of the tablet material with the die walls
sticking
happens when a part of the tablets gets sticks to
the punch surface, usually upper punch.
picking
complete or partial separation of the upper or
lower surface of the tablet horizontally, when the
tablet comes out of the die
Capping
tablet gets separated into layers
Laminating
usually happens around the tablet surface, small
pieces are broken out or chipped out of the
tablet.
Chipping
uneven distribution of the color on the surface of
the tablet
Mottling
seen when the tablet punches have engraving or
monograms on it to be embossed on the tablet
DOUBLE PRESS OR IMPRESSION
Tablets with additional layers of coating
materials
COATED TABLETS
Protects drugs that are moisture-sensitive prior subcoating
Waterproofing & sealing*
Attain fine smoothness and the appropriate color
Finishing and coloring
Bond sugars to tablet & rounding of tablet, this is repressed until desired shape and size is achieved
subcoating
Achieve desired glass
Polishing
Imprinting may be done prior
Polishing
shellac or pharmaceutical polymers
Waterproofing & sealing
Thin syrup + colorant
Finishing and coloring
Syrup plus coating enhancers such as gelatins, acacia, PVP to when slightly dry: apply dusting powder
Subcoating
