Study Set Content:
• The transition to addiction is determined by a combination of () factors
environmental and genetic
CANNABINOIDS Source
marijuana - Cannabis sativa
Psychoactive principle
A' THC
causes disinhibition of dopamine neurons, mainly by presynaptic inhibition of GABA neurons in the VTA.
THC
on chronic use
Relaxation, euphoria, decreased memory, pulmonary toxicity
CANNABINOID CI
Dronabinol & Tabilone
: Dronabinol & Tabilone - synthetic analogues approved for CINV and as
appetite stimulant.
s produced during the metabolism of GABA, but the function of this endogenous agent is unknown at present.
GAMMA-HYDROXYBUTYRIC ACID
GHB was first synthesized in 1960 and introduced as a
general anesthetic
It can however be prescribed (under restricted access rules) to treat (), because GHB decreases daytime sleepiness and episodes of cataplexy through a mechanism unrelated to the reward system.
narcolepsy
Before causing sedation and coma, GHB causes
euphoria, enhanced sensory perceptions, a feeling of social closeness, and amnesia.
These properties have made it a popular () that goes by colorful street names such as ()() or ()it is odorless and can be readily dissolved in beverages.
"club drug", "liquid ecstasy," "grievous bodily harm," "date rape drug."
It is rapidly absorbed after ingestion and reaches a maximal plasma concentration() minutes after ingestion of a()dose. The elimination half-life is about ()
20-30, 10-20 mg/kg , 30 minutes.
PSYCHEDELIC AGENTS
o Mescaline, Psilocybin & Psilocin o Dimethyltryptamine, LSD, Ecstacy
What is it?
Lysergic acid diethylamide
How does it work? - It interacts with() receptors in the midbrain.
5-HT
What are the physiologic actions of LSD on the CNS?
Visual hallucinations and flashbacks, Arousal Excitation, Disturbed perception, and Disturbed mood Panic
What are the peripheral physiologic effects?
Mydriasis, Tachycardia, Flushing, lacrination, salivation, and Increased blood pressure.
PCP/'Angel Dust"
PHENCYCLIDINE
o Not a true hallucinogen, pharmacologically similar to Ketamine.
PHENCYCLIDINE
