Study Set Content:
VASOCONSTRICTOR
TXA2
PGF 2α
Isoprostane 8-iso-PGF 2α (iPF 2
αIII)
VASODILATOR
PGI2 and PGE2
PGD2
dominant mediator of flushing and used by the
lipid lowering drug, niacin
PGD 2
Most prostaglandins and thromboxanxes activate
gastrointestinal smooth muscle
LONGITUDINAL
MUSCLE is contracted
by
PGE2
PGF
PGE2 (via
EP 3)
PGF 2a (via
FP
CIRCULAR MUSCLE is
contracted by STRONGLY BY
PGF 2a
CIRCULAR MUSCLE is
contracted by
WEAKLY BY
PGI2
CIRCULAR MUSCLE is
contracted by RELAXED BY
PGE2 (VIA EP 4)
Administration of either results in
colicky cramp
also have powerful contractile effects
Leukotrienes
AIRWAYS
RELAXATION
PGE 2 and PGI 2
AIRWAYS
CONTRACTION
PGD 2, TXA 2, and PGF 2a
According to studies of DP 1 and DP 2 receptor knockout
mice suggest an important role of this prostanoid in
asthma,
although the (blank) appears relevant to
allergic airway diseases.
DP 2 receptor
Bronchoconstriction by
cysteinyl leukotrienes
Bronchoconstriction by cysteinyl leukotrienes
- Stimulate bronchial mucus secretion and cause
mucosal edema
occurs in about 10% of people taking
NSAIDs, possibly because of a shift in arachidonate
metabolism from COX metabolism to leukotriene
formation.
Bronchospasm
Platelet aggregation is markedly affected by
eicosanoids
