Study Set Content:
can slow skeletal muscle healing.
COX inhibitors
may contribute to the bone loss that occurs
at menopause.
Prostaglandin
lower intraocular pressure.
PGE and PGF derivative
The mechanism of this action is unclear but probably
involves increased outflow of aqueous humor from the
anterior chamber via the
uveoscleral pathway
There has been significant interest in the role of
prostaglandins, and in particular the (blank), in
the development of malignancies.
COX-2 pathway
Pharmacologic inhibition or genetic deletion of (blank)
restrains tumor formation in models of colon, breast, lung,
and other cancers.
COX-2
In patients with(blank)(usually
inherited, cancer of the large intestine), COX inhibitors
significantly decrease
familial polyposis coli , polyp formation.
which is considered the principal oncogenic
prostanoid, facilitates tumor initiation, progression, and metastasis through multiple biologic effects, increasing
proliferation and angiogenesis, inhibiting apoptosis,
augmenting cellular invasiveness, and modulating
immunosuppression.
PGE 2,
generate compounds that can regulate
specific cellular responses important in inflammation and
immunity.
Lipoxygenases
affect nephron
transport functions either directly or via metabolism to
active compounds.
Cytochrome P450-derived metabolites
The biologic functions of the various forms of hydroxy- and
hydroperoxyeicosaenoic acids are largely unknown, but
their pharmacologic potency is
impressive
acting at the BLT 1 receptor, is a potent
chemoattractant for T lymphocytes, eosinophils,
monocytes, and possibly mast cells;
LTB 4,
are potent chemoattractants for eosinophils
and T lymphocytes.
cysteinyl
leukotrienes
Cysteinyl leukotrienes may also generate distinct sets
of cytokines through activation of mast cell
cysLT 1 and
cysLT 2.
concentrations, these leukotrienes also promote
eisonophil adherence, degranulation, cytokine or
chemokine release, and oxygen radical formation
higher
also contribute to inflammation
by increasing endothelial permeability, thus promoting
migration of inflammatory cells to the site of inflammation.
Cysteinyl leukotrienes
have been strongly implicated in the
pathogenesis of inflammation, especially in chronic
diseases such as asthma and inflammatory bowel
disease.
leukotrienes
have diverse effects on leukocytes, including
activation of monocytes and macrophages, and inhibition
of neutrophil, eosinophil, and lymphocyte activation.
Lipoxins
Both lipoxin A and lipoxin B inhibit
natural killer cell
cytotoxicity
Low concentration promotes vascular smooth
muscle cell proliferation and migration
12(S)- Hydroxyeicosatetraenoic acid
HETE
