Study Set Content:
What are the 5Rs in the inflammatory reaction?
Recognition, Recruitment, Removal, Regulation, Repair
Components of inflammatory response
Blood vessels & Leukocytes
Fundamental Response of Inflammatory Response
Consequences of the inflammatory response, Harmful Consequences of inflammation, Local and systemic inflammation, Mediators of inflammation, Acute and Chronic inflammation
Rubor
Redness
Tumor
Swelling
Calor
Heat
Dolor
pain
Functio laesa
Loss of function
Causes of Inflammation
Infections, tissue necrosis, Foreign bodies, immune reactions/hypersensitivity
For extracellular microbes
Plasma Membrane
for ingested microbes
The endosomes
For intracelluar microbes
Cytosol
Cellular receptor for microbes
Plasma membrane, The endosomes, and the cytosol
cytosolic receptors, such as NOD-like receptors (NLRs), that recognize diverse molecules that are liberated or altered as a consequence of cell damage
Sensors of cell damage
receptors recognize microbes coated with antibodies and complement and promote ingestion and destruction
Other cellular receptors involved in inflammation
What is the coating process called?
opsonization
recognizes microbial sugars and promotes ingestion of the microbes and the activation of the complement system
Mannose-binding lectin
Circulating Proteins
Mannose-binding lectin
sentinels that detect invaders and tissue damage
Macrophages, dendritic cells, and mast cells
What are mediators of inflammation?
Substances that initiate and regulate inflammatory reactions
