Study Set Content:
"ab initio" means?
from the beginning
Rapid response to infections and tissue damage
Acute
may follow acute inflammation or arise de novo
Chronic
Two types of vasoactive amines
Histamine and Serotonin
important actions on blood vessels; among the first mediators to be released
Histamine and Serotonin
Richest source of histamine
Mast Cells
Histamine and Serotonin, triggers what?
physical injury, binding of antigen to IgE antibodies, anaphylatoxins (C3a
and C5a), Neuropeptides (e.g., substance P) and cytokines (IL-1, IL-8)
what causes dilation of arterioles and increases the permeability of venules?
Histamine
principal mediator of the immediate transient phase of increased vascular permeability
Histamine
What blocks histamines?
antihistamines
Vasoactive mediator present in platelets and certain neuroendocrine cells, such as in the gastrointestinal tract
Serotonin
Neurotransmitter in the gastrointestinal tract and the central nervous system; Vasoconstrictor
Serotonin
what are produced from arachidonic acid (AA) in phospholipid membrane
Prostaglandins and leukotrienes
stimulate vascular and cellular reactions in acute inflammation
Arachidonic Acid Metabolites
they are derived from 20-carbon fatty acids; Greek eicosa \=
20
eicosanoids
Generate prostaglandins
cyclooxygenases
Produces leukotrienes and lipoxins
lipoxygenases
produced by mast cells, macrophages, endothelial cells
Prostaglandin
prostacyclin
PGI2
thromboxane A2 (TxA2)
platelet aggregation
