Study Set Content:
COX -1 is from what?
most tissues
COX - 2
inflammatory
produced in leukocytes and mast cells by the action of lipoxygenase
Leukotrienes
What converts AA to 5-hydroxyeicosatetraenoic acid, which is chemotactic for neutrophils
5-lipoxygenase
Vascular and smooth muscle reactions and leukocyte recruitment
Leukotrienes
Determine the action made:
Prostaglandins PGI2 (prostacyclin), PGEi, PGE2, PGD2
Vasodilation
Determine the action made:
Thromboxane A2, leukotrienes C4, D4, E4
Vasoconstriction
Determine the action made:
Leukotrienes C4, D4, E4
Increased vascular permeability
Determine the action made:
Leukotrienes B4, HETE
Chemotaxis, leukocyte adhesion
suppress inflammation by inhibiting neutrophil chemotaxis and adhesion to
endothelium
Lipoxins
Determine its source:
Histamine
Mast cells, basophils, platelets
Determine its source:
Prostaglandins
Mast cells, leukocytes
Determine its source:
Leukotrienes
Mast cells, leukocytes
Cytokines
Macrophages, endothelial cells, mast cells
Determine its source:
Chemokines
Leukocytes, activated macrophages
Determine its source:
Platelet activating factor
Leukocytes, mast cells
are proteins produced by many cell types dendritic cells, but
also endothelial, epithelial, and connective tissue cells) that mediate
and regulate immune and inflammatory reactions
Cytokines
critical roles in leukocyte recruitment by promoting adhesion of leukocytes to endothelium and their migration through blood vessels
Cytokines, Chemokines, TNF, IL - 1
Produced by t lymphocytes and mast cells
TNF
Produced by some epithelial cells
IL-1
