Study Set Content:
mediator of host inflammatory response to infections and other inflammatory stimuli.
IL-1
These cytokines increase the expression of adhesion factors on endothelial cells to enable transmigration of leukocytes to sites of infection and reset the hypothalamic thermoregulatory center,
IL-1
Promotes expansion of early blood cells (hematopoiesis) that differentiate into all known mature cell types. Supports growth and differentiation of T cells from bone marrow through immune response.
IL-3
Has high capacity to induce activation of almost all clones of cytotoxic cells
IL-2
Increases cytotoxic functions of T killer and NK cells; promotes production of perforins and IFN-γ by these cells.
IL-2
Activates monocytes-macrophages to synthesize and secrete TNF-α, IL-1β,
IL-6, IL-8, G-CSF, and GM-CSF.
IL-2
Induces differentiation of naive helper T cells (Th0 cells) to Th2 cells.
IL-4
Early activation of resting B cells—upregulates MHC class II production (induces HLA-DR molecules on B cells, macrophages) and governs B cell isotype switching to IgG1 and IgE.
IL-4
activate eosinophils and serve as link between T cell activation and eosinophilic inflammation.
IL-5
Growth and differentiation–inducing factor for activated T and B cells; induces class-specific B cell differentiation (IgA production).
IL-5
Stimulates proliferation of lymphoid progenitors; important for proliferation during certain stages of B cell maturation and in T cell and NK survival, development, and homeostasis.
IL-7
Functions in innate immunity and adaptive immunity; in the latter, stimulates growth of B cells that have differentiated into antibody producers.
IL-6
Potent stimulator of neutrophils in chemotaxis. Activates “respiratory burst” and release of specific and azurophilic granular contents.
IL-8
Promotes proliferation of T cells, thymocytes, and mast cells. Supports proliferation of some T cell lines and of bone marrow–derived mast cell progenitors; supports growth of erythroid blast-forming units.
IL-9
Although it shares functional properties of enhancing cytotoxic function of NK cells and activated T cells with IL-2; stimulating production of IFN-γ by NK and T cells, stimulating differentiation of naive T cells into Th1 cells, and enhancing cytolytic functions of activated NK cells and CD8+ Tc cells.
IL-12
Inhibits activated macrophages; displays potent abilities to suppress antigen presenting capacity of APCs; Released by cytotoxic T (Tc) cells to inhibit the actions of NK cells during immune response to viral infection.
IL-10
Acts in a manner similar to IL-6 on hematopoietic progenitor cells.
synergizes with IL-3 to stimulate production of megakaryocyte and myeloid progenitors and to increase number of g-secreting B lymphocytes in vivo and in vitro.
IL-11
Possesses many biological effects similar to IL-4 but appears to have less effect on T or B cells than IL-4; inhibit their activation and to antagonize IFN-γ.
IL-13
Acts as B-cell growth factor (BCGF) in proliferation of normal and cancerous B cells. enables progression of B-cell non-Hodgkin’s lymphoma (NHL-B); conversely, its antibodies slow down growth of NHL-B
IL-14
Biologically similar to IL-2; acts as synergist, particularly in LAK cell induction process; increases antitumoral activities of T-killer and NK cells and can be chemoattractant for T lymphocytes; endogenous IL-15 is key condition for IFN-γ synthesis.
IL-15
