Study Set Content:
Acts as a T-cell chemoattractant; increases mobility of CD8+ and CD4+ T cells and, with IL-2, promotes their activation; found in b lymphocytes
IL-16
Induces granulopoiesis through G-CSF; can reinforce antibody-dependent
tumor cell destruction; participates in regulation of many cytokines (IL-1,
IL-4, IL-6, IL-10, IL-12, IFN-γ).
IL-17
Acts as synergist with IL-12 in some effects, especially induction of IFN-γ
production and inhibition of angiogenesis
Il-18
Biological function similar to that of IL-10; regulates functions of macrophages
and suppresses activities of Th1 and Th2; LPS and GM-CSF is involved in this process
IL-19
stimulates production of IFN-γ by NK cells and T cells, synergistic with IL-12.
IL-18
Biological activities similar to those of IL-10 and can stimulate tumor growth.
Regulates proliferation and differentiation of keratocytes during inflammation,
particularly inflammation associated with the skin.
IL-20
Regulates hematopoiesis and immune response and influences development
of lymphocytes; similar to IL-2 and IL-15 in antitumor defense system;
IL-21
Newly discovered cytokine that shares some in vivo functions with IL-12; it enhances T cell priming and stimulates production of proinflammatory molecules (IL-1, IL-6, TNF-α, NOS-2, chemokines), resulting in inflammation.
IL-23
Similar to IL-10, but does not prohibit production of proinflammatory
cytokines through monocytes in response to LPS; somewhat similar to
IFN-α, -β, and -γ.
IL-22
Appears to participate in cell survival and proliferation by inducing rapid
activation of particular transcription factors called STAT-1 and STAT-3;
IL-24
Biologically characterized as a member of IL-17 cytokine family; Supports proliferation of cells in lymphoid lineage; Induces production of other cytokines (IL-4, IL-5, IL-13) in multiple tissues,
which stimulate the expansion of eosinophils.
IL-25
Induces rapid phosphorylation of transcription factors STAT-1 and STAT-3, which enhance IL-10 and IL-8 secretion and expression of CD54 molecule on surface of epithelial cells.
IL-26
Plays role in immune defense against viruses
IL-28
Has important function in regulating activity of B and T lymphocytes; belongs
to the IL-12 family.
IL-27
Plays important role in host defenses against microbes; its gene is highly
upregulated in cells infected with virus.
IL-29
a member of the long-chain four-helix bundle cytokine family, and EBI3 form the IL-27 heterdimer, which is expressed by APCs.
IL-30
Believed to play role in skin inflammation.
IL-31
Can induce cells of immune system (e.g., monocytes-macrophages) to secrete
TNF-α in addition to chemokines such as IL-8.
IL-32
Mediates biological effects by interacting with orphan IL-1 receptor, activating
intracellular molecules in certain signaling pathways that drive production of
type 2 cytokines (e.g., IL-4, IL-5, IL-13) from polarized Th2 cells
IL-33
Induces expression of TNF-α and IL-8 in THP-1 monocytic cells. Expression is induced in human peripheral lymphocyte cells after mitogen stimulation, in human epithelial cells by IFN-γ, and in NK cells after exposure to IL-12–IL-18 combination.
IL-32
