Study Set Content:
It reversibly inhibits cyclooxygenase-1 and - 2 (COX-1 and -2) isoenzymes, thereby reducing the synthesis of prostaglandins in body tissues.
INDOMETHACIN
History of ()- or () recent or active(), history of () or () related to previous NSAID use; severe .()
aspirin, NSAID-induced acute asthma, urticaria, or rhinitis; peptic ulcer gastrointestinal bleeding , perforation, heart failure
History of () or ()
proctitis , rectal bleeding
Use in the setting of () surgery.
coronary artery bypass graft (CABG)
Pregnancy
3rd trimester)
Severe () impairment.
renal and hepatic
Concomitant use with
diflunisal
Concomitant use with diflunisal
decreased renal clearance, increased plasma concentration; potentially fatal
A NSAID that is an anthranilic acid derivative, exhibiting analgesic, anti-inflammatory and antipyretic properties.
Mefenamic Acid
It reversibly inhibits cyclooxygenase-1 and -2 (COX-1 and -2), thus resulting in reduced rate of prostaglandin synthesis.
Mefenamic Acid
Mefenamic Acid Contraindications
Hypersensitivity
Patients with active or history of recurrent () , history of () (related to previous NSAID therapy), () disease,(), history of () reactions after taking aspirin or other NSAIDs
peptic ulcer/hemorrhage, gastrointestinal bleeding or perforation, inflammatory bowel, severe heart failure, asthma, bronchospasm, rhinitis, angioedema, urticaria, or allergic-type
Treatment of peri-operative pain in the setting of
CABG
() impairment.
Renal and severe hepatic
(CrCl
30 mL/min
Pregnancy
(3rd trimester)
exhibit analgesic, antiinflammatory, and antipyretic properties, and most inhibit platelet aggregation.
Nonsteroidal anti-inflammatory drug
Its anti-inflammatory effect is chiefly mediated through the inhibition o
prostaglandin biosynthesis.
3 STEPS IN TLC.
Spotting -
Development -
Visualization -
Prepare a very dilute solution of the sample in a volatile solvent. Apply a tiny drop of this on the plate.
Spotting -
