Study Set Content:
Receptor stimulant & Cholinesterase-inhibitors
ACETYLCHOLINE
• Makes up a large group of drugs that mimic acetylcholine () agents
cholinomimetic
ACETYLCHOLINE RECEPTORS (ACHR) OR CHOLINERGIC RECEPTORS
• Muscarinic (mAChR)
• Nicotinic (nAChR)
are drugs that mimic or potentiate the actions of acetylcholine
Cholinergic agonists
TWO TYPES OF ACETYLCHOLINE RECEPTORS (ACHR) OR CHOLINERGIC RECEPTORS
1. Muscarinic(mAChR)
2. Nicotinic (nAChR)
- found in ganglia, smooth muscle, myocardium, secretory glands & the CNS
M1 to M5 -
located in autonomic ganglia
Neuronal nicotinic (NN)
located in the neuromuscular junction
Muscular nicotinic (Nm)
WHERE IN THE BODY ARE CHOLINERGIC RECEPTORS FOUND? blank of the autonomic ganglia
Preganglionic fibers
WHERE IN THE BODY ARE CHOLINERGIC RECEPTORS FOUND?
that terminate in the adrenal medulla
• Preganglionic fibers
of the parasympathetic system
• Postganglionic fibers
of the somatic system CNS
Voluntary muscles
innervated by the postganglionic sympathetic nervous system
Sweat glands
TYPES OF CHOLINERGIC AGONISTS ARE AVAILABLE FOR CLINICAL USE?
DIRECT-ACTING AGONISTS
INDIRECT-ACTING AGONISTS
chemically bind with and activate muscarinic and nicotinic receptors in the body.
DIRECT-ACTING AGONISTS -
inhibit the enzyme acetylcholinesterase and therefore increase the concentration of acetylcholine within the synapse.
INDIRECT-ACTING AGONISTS
M2 Other names
Cardiac M2
Nm
Muscle type, end plate receptor
Nn
Neuronal type, ganglion receptor
M1 Location
Nerves
