Study Set Content:
SYNTHESIS OF ASPIRIN
CHEMICAL USED:
Salicylic acid
Acetic anhydride
Conc. H2SO4
Distilled water
chemical reaction formula
SALICYLIC ACID or
2-HYDROXYBENZOIC ACID
White crystals, fine needles or fluffy white crystalline powder
SALICYLIC ACID
SALICYLIC ACID BP-
211.0 °C @ 20.00 mmHg
MP-
- 158 °C
Very(blank) soluble in water
slightly
SALICYLIC ACID
Soluble in
organic solvents
Very soluble (in
ethanol
SALICYLIC ACID Pcol
anti-infective, anti-fungal, keratolytic, analgesic and antipyretic
Scaling conditions such as dandruff, ichthyosis and psoriasis
KERATOLYIC
KERATOLYIC Main risks with oral therapeutic doses are mostly
gastrointestinal irritation
has been reported in children who had taken aspirin for treatment of viral infections such as influenza
Hepatic encephalophaty (Reye’s Syndrome)
SALICYLYC ACID severe
occur as the principle secondary consequences
Metabolic acidosis, water and electrolyte loss
Central nervous system (CNS) toxicity include,
tinnitus, hearing loss
entral nervous system (CNS) toxicity include, tinnitus, hearing loss and in very severe cases particularly in children
convulsions and coma
Synthetically by heating
sodium phenolyate with carbon dioxide
Synthetically by heating sodium phenolyate with carbon dioxide +
under pressure
Synthetically by heating sodium phenolyate with carbon dioxide under pressure and microbial oxidation of
naphthalene
Salicylic acid
Natural methyl salicylate
