Study Set Content:
inhibits ATP synthase.
Oligomycin
– inhibits complex I (coenzyme Q binding site)
Rotenone (and some barbiturates)
• Rotenone is a broadly used pesticide, but more often in the US as a
piscicide
piscicide
fish
Rotenone blocks complex I from passing electrons from the
Fe-S clusters to ubiquinone.
is a fungicide that is no longer in use because of newer, more broad-spectrum agents
Carboxin
• Similar to rotenone, carboxin interferes with
ubiquinone at the binding site
Antimycin A is a
piscicide
Antimycin A is a piscicide that binds to
cytochrome c reductase
• Antimycin A is a piscicide that binds to cytochrome c reductase at the
Qi binding site.
This activity prevents ubiquinone from binding and accepting an electron, thereby blocking the
recycling of ubiquinol (CoQH2) by the Q cycle.
Carbon monoxide binds to and inhibits
cytochrome c oxidase
In addition to the disruption of the ETC, carbon monoxide also binds to
hemoglobin
In addition to the disruption of the ETC, carbon monoxide also binds to hemoglobin at an
oxygen-binding site
In addition to the disruption of the ETC, carbon monoxide also binds to hemoglobin at an oxygen-binding site converting it to
carboxyhemoglobin
In addition to the disruption of the ETC, carbon monoxide also binds to hemoglobin at an oxygen-binding site converting it to carboxyhemoglobin. In this state, (blank) is displaced from
oxygen
In addition to the disruption of the ETC, carbon monoxide also binds to hemoglobin at an oxygen-binding site converting it to carboxyhemoglobin. In this state, oxygen is displaced from hemoglobin, effectively blocking delivery to
body tissues
also binds to and inhibits cytochrome c oxidase
Cyanide
Oligomycin is a
macrolide
Oligomycin is a macrolide antibiotic synthesized by
Streptomyces species
