Study Set Content:
OBTAINED FROM Penicillium griseofulvum & other species: P. janczewski, P. nigrum, P.patulum
GRISEOFULVIN
used to treat fungal blepharitis, conjunctivitis & keratitis caused by susceptible organisms including species of Aspergillus, Candida, Cephalosporium, Fusarium & Pennicilium
NATAMYCIN
a drug of choice for keratitis caused by Fusarium solani
NATAMYCIN
used as a fungistatic in dermatophytoses
GRISEOFULVIN
A SEMISYNTHETIC ANTIBIOTIC DERIVED FROM RIFAMYCIN B, A METABOLITE OF Streptomyces mediterranei
RIFAMPICIN
PRODUCED BY Streptomyces niveus & S. spheroids
NOVOBIOCIN
- used as an alternate means for controlling penicillin- resistant staphylococci.
NOVOBIOCIN
also useful in controlling some strains of Proteus vulgaris, but due to its high incidence of adverse reactions its use is limited to serious infections when other less toxic drugs are ineffective or contraindicated.
NOVOBIOCIN
recommended for the treatment of pulmonary tuberculosis in combination with other antitubercular drugs. Patients should be advised that it may color stools, urine, saliva, sweat or tears a redorange.
RIFAMPICIN
THESE INCLUDES COMPOUNDS THAT ARE DERIVED DIRECTLY FROM CARBOHYDRATE PRECURSORS AND RETAIN A RECOGNIZABLE CARBOHYDRATE CHARACTER.
ANTIBIOTICS DERIVED FROM CARBOHYDRATE METABOLISM
These substances have() linked glycosidically to an amino-substituted cyclohexanyl aglycone.
2 to 3 uncommon sugars
Aminoglycoside antibiotics have a wide spectrum of activity, but these antibiotics are not absorbed following()
oral administration
The aminoglycosides are indicated only for the treatment of serious infections when less toxic antibiotics are
ineffective or contraindicate
Major toxic effects of aminoglycoside
Ototoxicity and Nephrotoxicity
Streptomycin
WAS ISOLATED FROM Streptomyces griseus by WAKSMAN AND COWORKERS IN 1944.
STREPTOMYCIN
WAS THE FIRST AMINOGLYCOSIDE ANTIBIOTIC TO BE DISCOVERED.
STREPROMYCIN
COMPONENTS:
STREPTIDINE
 STREPTOBIOSAMINE-
STREPTOSE
A DISACCHARIDE THAT CONTAINS 2-DEOXY-2-METHYLAMINO-LGLUCOSE
STREPTOBIOSAMINE
 IS THE FIRST LINE OF CHOICE FOR THE TREATMENT OF TUBERCULOSIS
STREPTOMYCIN
