Study Set Content:
it binds to the
50S subunit of microbial 70S ribosomes
they claimed to be the safest antibiotic available
MACROLIDES
THE ANTIBIOTIC OF CHOICE FOR THE TREATMENT OF Legionella pneumophilia.
ERYTHROMYCIN
OBTAINED FROM Streptomyces antibioticus
OLEANDOMYCIN
an alternate drug for erythromycin
OLEANDOMYCIN
obtained from Streptomyces erythreus
ERYTHROMYCIN
• A group of amphoteric actinomycete metabolites that are characterized by a series of conjugated double bonds.
POLYENES
These are unsaturated macrolides with macrolactone rings that are considerably larger than those of erythromycin and oleandomycin
POLYENES
They have no antibacterial activity. Their therapeutic utility is related to their
antifungal action.
hey are unstable and poorly absorbed from the intestinal tract & toxic when administered systemically.
POLYENES
TETRAENES
NYSTATIN o NATAMYCIN
HEPTAENES
AMPHOTERICIN B
o CANDICIDIN
The polyenes act by destroying the integrity of the () of susceptible organisms, this action is related to the binding of polyenes to steroids in the membranes & the formation of aqueous pores
cellular membrane
PRODUCED BY Streptomyces nodosus
AMPHOTERICIN B
PRODUCED FROM Streptomyces griseus
CANDICIDIN
PRODUCED BY Streptomyces noursei
NYSTATIN
used for the treatment of vaginal candidiasis in the form of ointment & a suppository
CANDICIDIN
used topically & parenterally for the treatment of potentially life-threatening dessiminated mycotic infections such as blastomycosis, systemic candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis & moniliasis.
AMPHOTERICIN B
used in the treatment of cutaneous, intestinal and vaginal infections of candida.
NYSTATIN
OBTAINED FROM Streptomyces natalensis
NATAMYCIN
