Study Set Content:
They should not be given with() to minimize bonding to food proteins and acid inactivation
food
is considered the agent of first choice against many pathogenic gram-positive bacteria.
Penicillin G
Penicillin G These include
• Bacillus anthracis
• Staphylococcus aureus
• Clostridium tetani
• Streptococcus pneumoniae
• Clostridium perfringes
• Β-haemolytic group A Streptococcus
The drug of choice in treating syphilis (Treponema pallidum) and infections caused by the gram (-) cocci, Neisseria gonorrhoeae and Neisseria meningitides
Β-haemolytic group A Streptococcus
1mg of pure pen g potassium is equivalent to
1595 units
Pen g potassium or
potassium benzyl penicillin
Maybe administered
orally, im or iv.
Pen g sodium or
sodium benzyl penicillin
is used as the reference standard for microbial assaysof penicillins
Pure pen g sodium
1mg is equivalent to
1667 units
Pen g sodium Used
orally, im or iv
Penicillin g benzathine • Or
n,n’ – dibenzylethylenediamine dipenicillin
Used im for its unusually() and orally for its rsistance to ()
prolonged duration of action , gastric inactivation.
Penicillin v or
phenoxymethyl penicillin
Penicillin of choice for oral administration
Penicillin v
Penicillin v Less susceptible to degradation by
gastric acid
Should be taken on an empty stomach (1 hour before or 2 hours after eating).
Penicillin v
Penicillin v 1mg is equivalent to
1695 units
PENICILLINASE-RESISTANT PENICILLINS
Cloxacillin
▪ Dicloxacillin
▪ Methicillin
▪ Nafcillin
▪ Oxacillin
Semisynthetic penicillins that are not inactivated by penicillinase.
PENICILLINASE-RESISTANT PENICILLINS
