Study Set Content:
Primarily recommended for the treatment of staphylococcal infections resistant to other
penicillins
is acid-labile and must be administered parenterally, but the remaining 4 are stable in gastric acidity
METHICILLIN
EXTENDED SPECTRUM PENICILLINS or
AMPICILLIN RELATED):
AMPICILLIN RELATED):
Ampicillin or aminobenzyl penicillin
▪ Amoxicillin
▪ Bacampicillin
▪ Cyclacillin
All are stable in gastric acid and readily absorbed
EXTENDED SPECTRUM PENICILLINS
EXTENDED SPECTRUM PENICILLINS Effective agains
p. Mirabilis, e. Coli, h. Influenzae.
the agent of choice in the primary treatment of uncomplicated gonorrhea
AMOXICILLIN-
EXTENDED SPECTRUM PENICILLINS (ACTIVE AGAINST P. AERUGINOSA)
• Carbenicillin disodium- the drug of choice for P. Aeruginosa infections.
• Ticarcillin
• Mezlocillin
• Piperacillin
• Azlocillin
• Amdinocillin
• Penicillins combined with clavulanic acid
e drug of choice for P. Aeruginosa infections.
Carbenicillin disodium
Β- lactam antibiotics _they inhibit the cell wall formation
CEPHALOSPORINS
They are similar to penicillin’s
CEPHALOSPORINS
CEPHALOSPORINS Route
oral and parenteral
CEPHALOSPORINS Spectrum of activity
broad spectrum
broad spectrum, but they are not active against
enterococci and l. Monocytogenes
FIRST GENERATION
Cephradine
▪ Cefadroxil
▪ Cefazolin
▪ Cephalexin
▪ Cephalothin
▪ Cephapirin
These drugs are very active against () cocci such as
gram (+)
These drugs are very active against gram (+) cocci such as
pneumococci, streptococci & staphylococci
Its antibacterial activity is similar to that of
ampicillin
Gram (-) that are sensitive to these cephalosporins:
H. Influenza, E. Coli, Proteus mirabilis, K. Pneumoniae
It is a drug of choice for surgical prophylaxis • It penetrates well into most tissues.
CEFAZOLIN
