Study Set Content:
first brand name
Chloromycetin
ADVERSE EFFECTS:
Aplastic anemia
Gray baby syndrome
o Bone marrow
o Suppression leukemia
most serious s/e of chloramphenicol treatment
Aplastic anemia-
– produced by streptomyces lincolnensis
Lincomycin
synthetically derived from lincomycin
Clindamycin
These antibiotics inhibit protein synthesis by a mechanism closely related to that of chloramphenicol and erythromycin. They all bind to the same site on the
50s subunit of 70s ribosomes.
Clindamycin is more () than lincomycin
rapidly and completely absorbed
produced by cultures of Streptomyces orchidaceus or by synthesis
CYLCLOSERINE
- probably the simplest metabolite with useful antibiotic activity
d-4-amino-3-isoxazolidinone
it is considered an antibiotic of second choice and is most frequently employed in combination with isoniazid in treating tubercular patients who fail to respond to streptomycin
CYLCLOSERINE
Dactinomycin or
actinomycin d
Obtained from streptomyces parvullus
DACTINOMYCIN
It is an () and is used for hospital treatment of () and several other types of carcinoma and sarcoma
antineoplastic agent, wilms’ tumor
A purine nucleoside obtained from streptomyces antibioticus
VIDARABINE
VIDARABINE It has an antiviral activity against
herpes simplex virus type 1 and 2.
It is indicated for the treatment of encephalitis caused by herpes simplex
VIDARABINE
Contains both d and l amino acids with antibiotic activity.
THE POLYPEPTIDES
These antibiotics are not absorbed from the(), and () is a potential problem if used systemically.
intestinal tract, nephrotoxicity
These includes:
o Polymyxin B
o Colistin
o Bacitracin
o Vancomycin
o Bleomycin
o Capreomycin
o Tyrothricin
Bacillus polymyxa → gram (-) infection
POLYMYXIN B
