Study Set Content:
→ Bacillus polymyxa → UTI & SOME g (-) bacilli (polymyxin E)
COLISTIN
Bacillus subtilis → gram (+) & some g (-) & topically as zinc salt
BACITRACIN →
Streptomyces capreolus → antitubercular agent
CAPREOMYCIN
Streptomyces orientalis → septicaemia or endocarditis caused by staphylococc
VANCOMYCIN
Streptomyces verticillus → palliative effect in some squamous cell carcinomas, lymphomas, testicular carcinomas, soft tissue sarcomas
BLEOMYCIN
ANTIBIOTICS DERIVED FROM ACETATE METABOLISM
• TETRACYCLINES
• ANTINEOPLASTIC ANTHRACYCLINE DERIVATIVES • MACROLIDES
• POLYENES
• GRISEOFULVIN
naturally occuring tetracyclines
o Chlortetracycline
o Demeclocycline
o Oxytetracycline
o Tetracycline
Semi-synthetic tetracyclines
o Doxycycline
o Methacycline
o Minocycline
Tetracycline
are a group of actinomycete antibiotics that have a broad spectrum and therapeutic utility.
Tetracyclines
Obtained from streptomyces species by () or by() of natural products.
fermentation , chemical transformation
Tetracyclines are considered the antibiotics of choice for the treatment of
brucellosis, cholera, relapsing fever, and infections
Tetracyclines are considered the antibiotics of choice for the treatment of brucellosis, cholera, relapsing fever, and infections caused by
chlamydia, mycoplasma, yersinia (pasteurella) and rickettsia
are used to treat a wide variety of infections including acne, septicemia, endocarditis and meningitis.
Tetracylines
Tetracyclines exert their action by inhibiting
protein synthesis.
The antibiotics interfere with the binding of aminoacyl-trna to acceptor sites on the () subunit of microbial () ribosomes.
30s, 70s
• Adverse Effects
Diarrhea
o Vomiting
o Staining of teeth
o Nausea
o Photosensitivity
The first tetracycline antibiotic available for therapeutic purposes. o Employed in veterinary medicine.
CHLORTETRACYCLINE- OR 7 CHLOROTETRACYCLINE
The least expensive and most commonly utelized tetracyline antibiotic. o Used in the treatment of severe cases of acne
TETRACYCLINE
Used as the base or the calcium salt as an antibacterial and as an adjunct in the treatment of amebiasis.
• OXYTETRACYLINE – OR 5- HYDROXYTETRACYCLINE
