Study Set Content:
• OXYTETRACYLINE – OR 5- HYDROXYTETRACYCLINE Available
orally, parenterally and topically
Used orally as the HCL salt
DEMECLOCYCLINE – OR 7-CHLORO-6- DEMETHYLTETRACYCLINE
Prepared from oxytetracycline by chemical dehydration and reduction.
DOXYCYCLINE – OR 6- DEOXY-5- HYDROXYTETRACYCLINE
Prepared from oxytetracycline by chemical dehydration.
METHACYCLINE
Prepared by reductive methylation of 7- nitro- 6- demethyl-6-deoxytetracycline.
MINOCYCLINE
Effective for the treatment of Neisseria gonorrhoeae.
MINOCYCLINE
ANTINEOPLASTIC ANTHRACYCLINE DERIVATIVES
• PLICAMYCIN
• DOXORUBICIN
• DAUNORUBICIN
• MITOMYCIN C
PRODUCED BY Streptomyces agrillaceus & S. plicatus.
PLICAMYCIN
PRODUCED BY Streptomyces coeruleorubidus.
DAUNORUBICIN
PRODUCED BY Streptomyces peucetius.
DOXORUBICIN
PRODUCED BY Streptomyces caespitosus
MITOMYCIN
indicated for the treatment of disseminated testicular carcinoma when surgery and radiation are contraindicated.
PLICAMYCIN
sed in the treatment of some acute leukemias, soft tissue sarcomas, breast cancer & several types of carcinoma.
DOXORUBICIN
used to treat acute lymphocytic & nonlymphocytic leukemias
DAUNORUBICIN
useful in the treatment of disseminated adenocarcinoma of the stomach o pancreas.
MITOMYCIN
an alternate drug in advanced metastatic conditions of various types that have become resistant to other chemotherapeutic agents
MITOMYCIN
CHARACTERIZED BY A MACROLACTONE RING THAT IS GLYCOSIDICALLY LINKED TO 1 OR MORE SUGARS.
MACROLIDES
These includes:
erythromycin oleandomycin
these drugs are produced by
actinomycete fermentation
the macrolides exert their action by inhibiting the synthesis of
essential proteins.
