Study Set Content:
Tuberculin P.P.D.
Palpable induration 10mm or more
are bacterial waste products that are considered poisonous to the animal body
Toxins
they act as antigens because of their power to stimulate certain cells of the body to produce antibodies called
antitoxins
toxins are excreted from the bacterial cells producing them and are dissolved in the surrounding culture medium
Exotoxins
retained within the bacterial body
Endotoxins:
source of the most poisonous poison
CLOSTRIDIUM BOTULINUM
Compared to other toxins, botulinum toxin has a potency range () higher
10- 1000 times
Ingestion of exotoxin can cause
death
Treated with formaldehyde
Fluid Toxoids
precipitating or adsorbing the fluid toxoid with alum, aluminum hydroxide, or aluminum phosphate; more prone to produce local reactions at the site of injection than are fluid toxoids
Adsorbed Toxoid
Used to produce active immunity against
diphtheria and tetanus
DTP: triple antigen;
diphtheria, tetanus, pertussis
prepared from the blood of animals, usually horses, that have been immunized by repeated injections of specific bacterial exotoxins
ANTITOXINS
Prepared in 2 methods
Precipitation using ammonium sulfate
Pepsin solution to digest the plasma removing 80% of the protein
pseudoglobulin fraction is
s redissolved, dialyzed and filtered
digested material is treated with
ammonium sulfate
Pepsin solution to digest the plasma removing 80% of the protein; digested material is treated with ammonium sulfate it is
redissolved, dialyzed and filtered
Sensitivity testing should be done before administration - intracutaneous inj
0.02ml
Sensitivity testing should be done before administration - intracutaneous inj 0.02ml of
1:100 dilution
Eye drop on one eye 1:100 dilution into the
conjunctival sac
