Study Set Content:
probably play an important role
A 1A receptors
This effect explains why urinary retention is a potential adverse effect of administration of the a1 agonist
midodrine
Alpha receptor activation in the ductus deferens, seminal vesicles, and prostate plays a role in
normal ejaculation
The detumescence of erectile tissue that normally follows ejaculation is also brought about by
norepinephrine
contain adrenoceptors that regulate the secretion of amylase and water. However, certain sympathomimetic drugs, eg, clonidine, produce symptoms of dry mouth.
The salivary glands
The mechanism of this effect is uncertain; it is likely that central nervous system effects are responsible, although peripheral effects may
contribute
The apocrine sweat glands, located on the palms of the hands and a few other areas,respond to adrenoceptor stimulants with
increased sweat production.
These are the apocrine nonthermoregulatory glands usually associated with
psychological stress
The diffusely distributed thermoregulatory eccrine sweat glands are regulated by sympathetic cholinergic postganglionic nerves that activate
muscarinic cholinoceptors
leads to increased lipolysis with enhanced release of free fatty acids and glycerol into the blood.
Activation of B adrenoceptors in fat cells
also contain a 2 receptors that inhibit lipolysis by decreasing intracellular CAMP
Human fat cells
Sympathomimetic drugs enhance (blank) in the liver, which leads to increased glucose release into the circulation.
glycogenolysis
Activation of B, adrenoceptors by endogenous epinephrine or by sympathomimetic drugs promotes the uptake of potassium into cells, leading to a fall in
extracellular potassium.
Blockades of these receptors may accentuate the rise in plasma potassium that occurs during
exercise
Beta receptors that are expressed in pancreatic islets tend to(blank)insulin
secretion, respectively, although the major regulator of insulin release is the plasma concentration of glucose
increase and decrease
is stimulated by ß receptors and inhibited by a 2 receptors. Similarly, (blank) is stimulated by B 1 and inhibited by a 2 receptors;
Insulin secretion, renin secretion
B-receptor antagonist drugs may lower blood pressure in patients with hypertension at least in part by lowering
plasma renin.
are important endogenous regulators of hormone secretion from a number of glands.
Catecholamines
Adrenoceptors also modulate the secretion of ____ however, the physiologic significance of these control mechanisms is probably limited.
parathyroid hormone, calcitonin, thyroxine, and gastrin;
In high concentrations, epinephrine and related agents cause ____ (abnormally increase WBC), in part by promoting demargination of sequestered white blood cells back into the general circulation.
leukocytosis
