Study Set Content:
include dobutamine and a partial agonist, prevalterol.
Beta 1-selective agents
Because they are less effective inactivating vasodilator $2 receptors, they may increase cardiac output with less reflex tachycardia than occurs with nomelective agonists such as
isoproterenol
was initially a relatively selective agonist, but its actions are more complex commidered. Its chemical structure resembles dopamine, but its actions are mediatedmostlybyactivation of a and b receptors
Dobotamine
occurs in various plants and has been used in China for over 2000 year. It was introduced medicine in1924 as the first orally active sympathomimetic drug
Ephedrine
a popular herbal medication contains multiple ephedrine-like alkaloids in addition to ephedrine.
Mahuang,
non-catechol phenylisopropylamine it has high bioavailability and a relatively long duration of action-hours rather than
minutes
A significant fraction of the drag is excreted unchanged in the urine. Since it is a weak base, its excretion can be accelerated by (blank) of the urine.
acidification
Activate receptors accounted for earlier use in asthma because it gains access to the central nervous system, it is a mild
stimulant
one of four ephedrine enantiomers, has been available over the counter as a component of main decongestant mixture
Pseudoephedrine
However, the use of pseudoephedrine as a precursor in the illicit manufactures of amphetamine has led to its
constrictions
was a common component in over-the-counter appetite suppressan
Phenylpropanolamine
It was removed from the market because its use was associated with hemorrhagic strokes in
young women
The mechanism of this potential adverse effect is unknown, but the drug can increase blood pressure in patients with impaired
autonomic reflexes
Indirect-Acting Sympathomimetics: can have one of two different mechanisms.
➢ First, they may enter the sympathetic nerve ending and displace stored catecholamine transmitter. Such drugs have been called amphetamine like or
"displacers."
Second, they may () of released transmitter by interfering with the action of the norepinephrine transporter,NET
inhibit the reuptake
is a racemic mixture of phenylisopropylamine that is important chiefly because of its use and misuse as a central nervous system stimulant.
Amphetamine
Pharmacokinetically, it is similar to ____, however, amphetamine even more readily enters the central nervous system, where it has marked stimulant effects on mood and alertness and a depressant effect on appetite.
ephedrine
is more potent than the L-isomer Amphetamine's actions are mediated through the release of norepinephrine and, to some extent, dopamine.
Its D-isomer
(N-methylamphetamine) is very similar to amphetamine with an even higher ratio of central to peripheral actions.
Methamphetamine
is a variant phenylisopropylamine with amphetamine-like effects. It has been promoted as an anorexiant and is also a popular drug of abuse.
Phenmetrazine
