Study Set Content:
is an amphetamine variant whose major pharmacologic effects and abuse potential are similar to those of amphetamine.
Methylphenidate
effective in some children with attention deficit hyperactivity disorder
Methylphenidate
is a psychostimulant that differs from amphetamine in structure, neurochemical profile, and behavioral effects.
Modafinil
It (blank) both norepinephrine and dopamine transporters, and it increases (blank) not only of norepinephrine and dopamine, but also of (), while decreasing
inhibits , synaptic concentrations, serotonin and glutamate, GABA levels.
Used primarily to improve wakefulness in ____. It is associated with mild increases in blood pressure and heart rate.
narcolepsy
is a normal by product of tyrosine metabolism in the body and can be produced in high concentrations in protein-rich foods by decarboxylation of tyrosine during fermentation.
Tyramine
It is readily metabolized by____ in the liver and is normally inactive when taken ceally because of a very high first-pass effect, le, low bioavailability
MAO
Administered parenterally, it has an indirect sympathomimetic action caused by the release of stored
catecholamines.
Tyramine's spectrum of action is similar to that of
norepinephrine.
Patients taking MAO inhibitors must be very careful.to
tramine: containing foods
B. Catecholamine Reuptake inhibitors
• Many inhibitors of the amine transporters for norepinephrine, dopamine. and serotonin are used
clinically
Many antidepressants, particularly the____, can inhibit norepinephrine and serotonin reuptake to different degrees.
older tricyclic antidepressants
can induce orthostatic hypotension presumably by their clonidine-like effect or by blocking α 1 receptors, but the mechanism remains unclear
Imipramine,
is a selective inhibitor of the norepinephrine reuptake transporter.
Atomoxetine
Its actions are mediated by potendation of norepinephrine levels in
noradrenergic synapses
Used in the treatment of
attention deficit disorders
Has a ____ in the central nervous system to decrease spumerk outflow while same time potentiating the effects of norepinephrine in the periphery However, may increase bood pressure in some patients
clonidine-like effect
and other norepinephrine reuptake inhibition frequently cause orthostatachycardia
Atomoxetine
has similar characteristics as atomoxetine
Rebosetine
is a widely used antidepressant with balanced serotonin and norepinephrine reuptake inhibitory effects.
Duloxetine
