Study Set Content:
Duloxetine and milinacipran, another serotonin and norepinephrine tramporter blocker, are approved for the treatment of pain in
Fibromyalgia.
is a local anesthetic with a peripheral sympathomimetic action that results from inhibition of transmitter reuptake at noradrenergic synapses
Cocaine
It readily enters the central nervous system and produces as amphetamine like psychological effect that is shorter lasting and more intense than
amphetamine
The major action of cocaine in the central nervous system is inhibit ____into neurons in the pleasure centers of the brains
dopamine reuptake
Rapid cent action can be obtained when smoked snorted in the nose, or injected, has made cocaine a
heavily abused drug
which is converted to dopamine in the body, and dopamine agonists with central actions are of considerable value in the treatment of Parkinson's disease and prolactinemia
Levodopa,
is a D 1-receptor agonist that selectively leads to peripheral vasodilation in some vascular beds.
Fenoldopam
The primary indication for fenoldopamis in the intravenous treatment of
severe hypertension
may occur in a variety of settings such as severe hemorrhage, decreased blood volume, cardiac arrhythmias, neurologic disease or
accidents, adverse reactions or overdose of medications such as antihypertensive drugs, and infection.
Acute hypotension
Racing the patient in the ____ and ensuring adequate fluid volume while the primary problem is determined and treated is usually the correct course of action
recumbent position
Direct-acting a agonists such as norepinephrine, phenylephrine, and methoxamine have been used in this setting when
vasoconstriction is desired
is a complex acute cardiovascular syndrome that results in a critical reduction in perfusion of vital tissues and a wide range of systemic effects.
Shock
is usually associated with hypotension, analtered mental state, oliguria and metabolic acidosis
Shock
➢ If untreated, shock usually progresses to a refractory deteriorating state and
death
The three major mechanisms responsible for shock
hypovolemia, cardiac insufficiency, and altered vascular resistance
and treatment of the underlying disease are the mainstays of the treatment of shock.
Volume replacement
On standing, gravitational forces induce venous pooling, ring in
decreased venous rebum
Normally, a decrease in blood pressure is prevented by reflex the activation with increased heart rate, and peripheral arterial and
venous vasoconstriction.
Impairment of autonomic reflexes that regulate blood pressure can lead to chronic
orthostatic hypotension.
This is due to medications that can interfere with autonomic function lieg, imipramine and bicyclic and depressants, a blockers for the treatment of urinary retendon and diuretical diabetes, and other diseases causing
peripheral autonomic neuropathics.
