Study Set Content:
However, (blank), by limiting blood flow to the
liver, may impair disposition of those drugs whose
metabolism is flow-limited
cardiac disease
These drugs are so readily metabolized by the liver that
hepatic clearance is essentially equal to
liver blood flow
The impaired enzyme activity or defective formation of
enzymes associated with heavy metal poisoning or
(blank) also results in reduced hepatic drug metabolism.
porphyria
may also affect drug metabolism,
as indicated by the impaired hydrolysis of procainamide
and procaine in patients with chronic respiratory
insufficiency
Pulmonary disease
increased half-life of (blank) (a
P450 functional probe) in patients with lung cancer.
antipyrine
other factors affecting drug metabolism
Thyroid dysfunction
• Hypothyroidism
Malfunctions of the pituitary, adrenal cortex, and gonads
markedly reduce hepatic drug metabolism in
rats
Finally, the release of inflammatory mediators,
(blank) associated with bacterial or
viral infections, cancer, or inflammation are known
to impair drug metabolism by inactivating P450s and
enhancing their degradation.
cytokines, and nitric oxide
is found to inactivate CYP2B1
by modification of both its heme and protein
moieties
secobarbital
is
more potent than morphine itself.
morphine-6-glucuronide
