Study Set Content:
(myasthenia gravis, curare-induced neuromuscular paralysis),
neuromuscular junction
Cholinesterase inhibitors are occasionally used in the treatment of _____ and, very rarely, in the therapy of certain atrial arrhythmias.
atropine overdose
is a disease characterized by increased intraocular pressure.
• Glaucoma
• Glaucoma two main types
Open-angle glaucoma, Closed-angle glaucoma
the drainage angle formed by the cornea and the iris remains open, but the drainage channels (trabecular meshwork) in the angle are partially blocked, causing the fluid to drain out of the eye too slowly.
Open-angle glaucoma
Open-angle glaucoma - the drainage angle formed by the cornea and the iris remains open, but the drainage channels (trabecular meshwork) in the angle are partially blocked, causing the fluid to drain out of the eye too slowly. This causes fluid to back up in your eye, and pressure gradually (blank) within your eye.
increases
also called closed-angle glaucoma, occurs when the iris bulges forward to narrow or block the drainage angle formed by the cornea and the iris. As a result, fluid can't adequately flow through and exit your eye, and your eye pressure may increase abruptly. Angleclosure glaucoma usually occurs suddenly (acute angle-closure glaucoma), but it can also occur gradually (chronic angle-closure glaucoma)
Angle-closure glaucoma
reduce intraocular pressure
Muscarinic stimulants and cholinesterase inhibitors
In the past, glaucoma was treated with either
direct agonists or cholinesterase inhibitors
For (blank) these drugs have been largely replaced by topical blockers and prostaglandin derivative
chronic glaucoma,
strabismus caused by hypermetropic accommodative error) in young children is sometimes diagnosed and treated with cholinomimetic agonists.
Accommodative esotropia
Dosage is similar to or higher than that used for
glaucoma
Esotropia
Exotropia
Hypertropia
may occur postoperatively or postpartum or may be secondary to spinal cord injury or disease (neurogenic bladder).
Urinary retention
Cholinomimetics are also sometimes used to increase the tone of the lower esophageal sphincter in patients with
reflux esophagitis
Cholinomimetics are also sometimes used to increase the tone of the lower esophageal sphincter in patients with reflux esophagitis. • Of the choline esters, (blank) is the most widely used for these disorders
bethanechol
Bethanechol • For gastrointestinal problems, administered (blank) in a dose of (blank)
orally, 10-25 mg TID.
Bethanechol
In patients with urinary retention can be given (blank) in a dose of (blank) and repeated in 30 minutes if necessary.
SQ, 5 mg
