Pharmacrystal

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www.pharmacrystalniper.blogspot.com

16

Pharmacokinetics: 

Drug Metabolism

1.1) Which of the following locations is the  most likely for finding a free, unaltered drug?
       a) Urine
       b) Feces
       c) Breast milk
       d) Fat
       e) Sweat
1.2) Most drugs are active in their ____ form and inactive in their ____ form.
       a) Non-polar; Polar
       b) Polar; Non-polar
       c) Water-soluble; Lipid-soluble
       d) Lipid-insoluble; Water-insoluble
       e) Neutral; Neutral
2.1) Drug biotransformation phase I makes drugs ____ polar for metabolism and phase II
makes drugs ____ polar for excretion.
       a) More; More
       b) More; Less
       c) Less; More
       d) Less; Less
2.2) Which of the following is NOT a phase II substrate?
       a) Glucuronic acid
       b) Sulfuric acid
       c) Acetic acid
       d) Amino acids
       e) Alcohol
3) Which of the following reactions is phase II and NOT phase I?
       a) Oxidations
       b) Reductions
       c) Conjugations
       d) Deaminations
       e) Hydrolyses
4) Which of the following metabolically active tissues is the principle organ for drug
metabolism?
       a) Skin
       b) Kidneys
       c) Lungs
       d) Liver
       e) GI Tract
5.1) Damage at which of the following locations would most affect the goals of phase II
biotransformation?
       a) Skin
       b) Kidneys
        c) Lungs
        d) Liver
        e) GI Tract