Study Set Content:
Starch-iodine solution is channel-type complex consisting of
iodine molecules
Starch-iodine solution is channel-type complex consisting of iodine molecules entrapped within spirals of the
glucose residues
an interfering substance in the assay of dienesterol, could be extracted easily from dermatologic creams by channel-type inclusion in urea.
Monostearin
the principal constituent of bentonite, can trap hydrocarbons, alcohols, and glycols between the layers of their lattices
Clay montmorillonite,
can also intercalate compounds between its layers.
Graphite
crystallize in the form of a cage-like lattice in which the coordinating compounds is entrapped.
clathrates
are not involved in these complexes, and only the molecular size of the encaged component is of importance
Chemical bonds
Highly toxic agent (blank) crystallizes in cage-like hydrogen-bonded structures.
hydroquinone (quinol)
One official drug, (blank) is a clathrate of water, isopropyl alcohol, and sodium warfarin in the form of a white crystalline powder.
warfarin sodium, USP
Monomolecular inclusion compounds:
CYCLODEXTRINS
Monomolecular inclusion compounds involve the entrapment of a single guest molecule in the cavity of one
host molecule.
Host-Cyclodextrins (CD) a cyclic oligosaccharides containing a minimum of
f six D- (+)-glucopyranose
Host-Cyclodextrins (CD) a cyclic oligosaccharides containing a minimum of six D- (+)-glucopyranose units attached by
a-1,4 linkages
Host-Cyclodextrins (CD) a cyclic oligosaccharides containing a minimum of six D- (+)-glucopyranose units attached by a-1,4 linkages produced by the action on starch o
Bacillus macerans amylase
Their ability to form Inclusion-compounds in aqueous solution is due to the typical arrangement of the
glucose untis
alpha
–6 glucose units
Beta
7 glucose units
gamma
8 glucose units
Complexation does not ordinarily involve the formation of
covalent bonds.
Cyclodextrins may increase or decrease the reactivity of the guest molecule depending on the nature of the reactions and the orientation of the molecule within the
CD cavity.
