Study Set Content:
Sample size
10
TYPE 1
TYPE 3
NP
TYPE 2
TYPE 1, 3, NP
TYPE 2
Sedimentation Volume
(𝑠𝑒𝑡𝑡𝑙𝑒𝑑 𝑣𝑜𝑙𝑢𝑚𝑒)/(𝑡𝑜𝑡𝑎𝑙 𝑣𝑜𝑙𝑢𝑚𝑒 𝑜𝑓 𝑠𝑢𝑠𝑝𝑒𝑛𝑠𝑖𝑜𝑛)
Ideal SV
1
TOTAL VOL
TOTAL VOL
SETTLES VOL
SETTLED VOL
Degree of Flocculation
β = (𝑢𝑙𝑡𝑖𝑚𝑎𝑡𝑒 𝑠𝑒𝑑𝑖𝑚𝑒𝑛𝑡𝑎𝑡𝑖𝑜𝑛 𝑣𝑜𝑙𝑢𝑚𝑒 𝑜𝑓 𝑓𝑙𝑜𝑐𝑐𝑢𝑙𝑎𝑡𝑒𝑑 𝑠𝑢𝑠𝑝.)/(𝑢𝑙𝑡𝑖𝑚𝑎𝑡𝑒 𝑠𝑒𝑑𝑖𝑚𝑒𝑛𝑡𝑎𝑡𝑖𝑜𝑛 𝑣𝑜𝑙𝑢𝑚𝑒 𝑜𝑓 𝑑𝑒𝑓𝑙𝑜𝑐𝑐𝑢𝑙𝑎𝑡𝑒𝑑 𝑠𝑢𝑠𝑝.)
Ease of Redispersability
_____ dispersible/redispersible with minimum agitation
• 100%
Particle size distribution
• Optical Microscopy
• Sedimentation Rate
Zeta Potential Determination
Repulsive forces bet
Molecules/particles
Higher zeta potential, _____ settling of suspensoids
slower
are the sterile dosage form intended for administration other than enteral route and exert their action by directly entering into the systemic circulation
Parenterals
Advantages OF PARENTERALS
• Quick onset of action
• Suitable for the drugs which are not administered by oral route
• Useful for unoperative, nauseous, or unconscious patients
• Useful for emergency situation.
• Duration of action can be prolonged by modifying formulation.
• Means of correcting serious disturbances of fluid and electrolyte balance.
