Study Set Content:
A solid dosage form in which one or more APIs are dispersed in a suitable base and molded or otherwise formed into a suitable shape
Suppositories
The word comes from the Latin term “supponere” which means?
A. To melt and mold
B. To place under
C. To substitute
D. To spread inside
intended for insertion into body orifices where they melt, soften, or dissolve and exert local or systemic effects.
Suppositories
Suppositories generally have been employed for 3 reasons:
Promote defecation
Treat anorectal diseases
Introduce drugs into the body
Using laxative suppositories, enemas
Promote defecation
like hemorrhoids
Treat anorectal diseases
General Pros of suppositories
ü Good alternative to oral route
ü Avoid nausea & vomiting
ü Low cost & lack of technical difficulty vs parenterals
u Used in palliative medicine where injections are frequently given
ü Fast onset of action
Cons of suppositories
☓ Aesthetics and stigma of violating a person’s dignity
☓ Potential rectal irritation
☓ Difficulty in titrating a correct dose
☓ Uncomfortable af ???
A solid dosage form that is inserted into a naturally occurring (nonsurgical) body cavity other than the mouth or rectum, including the vagina and urethra.
Inserts
Medication sticks are a convenient form for administering topical drugs.
Sticks
Give the three types of suppositories based on their route of administration.
Rectal
Vaginal
Urethral
Rectal shape
Bullet, torpedo, little finger
Rectal weight for adults
2 g
Rectal weight for children
1 g
Vaginal Other names
Pessaries
Vaginal shape
Globular, oviform, cone-shaped
Vaginal adults weight
5 g
Urethral Other names
Bougies
Urethral shape
Slender, pencil-shaped
Urethral weight adults
4 g male
2 g female
