Study Set Content:
Diarlyamine
Nitrile
Quaternary ammonium
Amidine
Ether
Alkyl alcohol
Amidinium
Amine oxide
Ketone and aldehyde
Thioether
Sulfoxide sulfone
When a basic functional group is converted to the corresponding conjugate acid, it too becomes
ionized
are neither acidic nor basic and are not electrically neutral
Quaternary ammonium compounds
The relative fit of each drug molecule with its target is a function of a number of physicochemical properties:
a. acid-base chemistry and related ionization, b. functional group shape and size, and c. three-dimensional spatial orientation.
completely donate and dissociate or accept a proton in aqueous solution to produce conjugate bases and acids
Strong acids and bases
By knowing if there are acidic and/or basic functional groups present in a molecule, one can predict whether a molecule is going to be predominantly ionized or un-ionized at a given
pH
High pH
small intestine
Low pH
stomach
Being in its ionized form enhances water solubility as a consequence a shorter residency time for a drug to give its activity. Why? Because an ionized form has a polar characteristic (so ind sya ma distribute) leading to
excretion of this drug
The activity is that drug need to traverse onto the fatty cell membrane and that should be in its
unionized form
