benzodiazepines (including
chlordiazepoxide) [Librium]
diazepam
[Valium
carbamate meprobamate
[Miltown
based on random screening of newly synthesized chemicals.
carbamate meprobamate [Miltown])
Psychopharmacologic agents
The discovery of these drugs was based on observations of effects on the behavior of animals used in screening
bioassays
Chlorpromazine HCl
Chlordiazepoxide HCl
Meprobamate Milltown
observed unusual and characteristic paralysis and relaxation of voluntary muscles in laboratory animals for different series of compounds.
Frank M. Berger
At this point, the treatment of ambulatory anxious patients with
meprobamate
psychotic patients with one of the
aminoalkylphenothiazine drugs
Structural modifications of benzodiazepine derivatives were undertaken, and a compound 5 to 10 times more potent than chlordiazepoxide was synthesized in 1959 and marketed as
diazepam (Valium)
are used in the pharmacotherapy of anxiety and related emotional disorders and in the treatment of sleep disorders, status epilepticus, and other convulsive states.
Benzodiazepines
they are used as centrally acting muscle relaxants, for premedication, and as inducing agents in anesthesiology.
Benzodiazepines
Steroidal agents
Progesterone
Norethynodrel
Norethindrone
Mestronol