Study Set Content:
first synthesized the chlorpromazine in 1950
Paul Charpentier
Charpentier, who first synthesized the molecule in 1950 at
Rhone-Poulenc’s research laboratory;
who reported distinctive effects on animal behavior
Simone Courvoisier,
a French military surgeon who first noticed distinctive psychotropic effects in man;
Henri Laborit
French psychiatrists who clearly outlined what has now become its accepted use in psychiatry and without whose endorsement and prestige Rhone-Poulenc might never have developed it further as an antipsychotic?
Pierre Deniker and Jean Delay
Because of the bitter disputes over the discovery of (blank), no Nobel Prize was ever awarded for what has been the single most important breakthrough in psychiatric treatment.
chlorpromazine
The discovery of the antidepressant effects of the antitubercular drug (blank) led to a series of MAO inhibitor antidepressants
iproniazid (isopropyl congener of isoniazid) - monoamine oxidase (MAO)–inhibiting activity,
The discovery of the antidepressant effects of the antitubercular drug iproniazid (isopropyl congener of isoniazid) - monoamine oxidase (MAO)–inhibiting activity, led to a series of MAO inhibitor antidepressants including
phenelzine (Nardil)
tranylcypromine (Parnate).
introduced the first dibenzazepine (tricyclic) antidepressant
Ciba-Geigy
introduced the first dibenzazepine (tricyclic) antidepressant(blank)- a series of tricyclic compounds synthesized initially as structural analogs of phenothiazines, were developed.
imipramine
The tricyclic antidepressants are not antipsychotic, but instead elevate
mood
The tricyclic antidepressants are not antipsychotic, but instead elevate mood by blocking the transport inactivation of
monoamine neurotransmitters
The tricyclic antidepressants are not antipsychotic, but instead elevate mood by blocking the transport inactivation of monoamine neurotransmitters including
norepinephrine and serotonin
Selective serotonin reuptake or transport inhibitors (SSRIs) were developed, starting with
R,Szimelidine
Selective serotonin reuptake or transport inhibitors (SSRIs) were developed, starting with R,Szimelidine from
Astra Pharmaceutica
Selective serotonin reuptake or transport inhibitors (SSRIs) were developed, starting with R,Szimelidine from Astra Pharmaceutical (which proved to be
toxic
Selective serotonin reuptake or transport inhibitors (SSRIs) were developed, starting with R,Szimelidine from Astra Pharmaceutical (which proved to be toxic) and then
R,S fluoxetine (Prozac)
Selective serotonin reuptake or transport inhibitors (SSRIs) were developed, starting with R,Szimelidine from Astra Pharmaceutical (which proved to be toxic) and then R,S fluoxetine (Prozac) from
Eli Lilly and Compan
first commercially successful SSRI).
R,S fluoxetine (Prozac) from Eli Lilly and Company
The antianxiety agents:
benzodiazepines
diazepam
carbamate meprobamate
