Study Set Content:
Mifepristone
The 1 st pure hormone to be isolated from the endocrine gland was
epinephrine
The 1 st pure hormone to be isolated from the endocrine gland was epinephrine, which led to further molecular modifications in the area o
sympathomimetic amines
then was also identified from sympathetic nerves.
Norepinephrine
allowed the isolation and characterization of a multitude of hormones from a single gland
chromatographic techniques
isolated thyroxine from the thyroid gland and discover the activity of cortisone
Edward Kendall
Edward Kendall subsequently won the
Nobel Prize
two of the hormones of the thyroid gland have several effects on the body, regulating the metabolism
Thyroxine and Liothyronine
two hormones from the posterior pituitary gland:
Vasopressin
Oxytocin
which is responsible for the antidiuretic activity.
Vasopressin
stimulates lactation and uterine motility which actually differ considerably both in their chemical structure and physiological activity.
Oxytocin
A major achievement in drug discovery and development was the discovery of (blank) in 1921 from animal sources.
insulin
isolated the peptide hormone and began testing it in dogs.
➢ Frederick G. Banting and Charles H. Best
1922, researchers, with the help of (blank) and the pharmaceutical industry, purified and produced animal-based insulin in large quantities.
James B. Collip
Insulin soon became a major product for (blank)k, a Danish pharmaceutical company.
Eli Lilly & Co. and Novo Nordisk
were awarded the Nobel Prize in Medicine or Physiology, and after much controversy, they shared the prize with
McLeod and Bunting
McLeod and Bunting were awarded the Nobel Prize in Medicine or Physiology, and after much controversy, they shared the prize with
Collip and Best
For the next 60 years, (blank) were the major sources of insulin.
cattle and pigs
With the development of genetic engineering in the 1970s, new opportunities arose for making synthetic insulin that is chemically identical to human
insulin
1978 produced human insulin in the laboratory using recombinant DNA technology
Genentech and the City of Hope National Medical Center
